TEK (TEK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TEK include Venous Malformations, Multiple Cutaneous And Mucosal and Glaucoma 3, Primary Congenital, E. Among its related pathways are RET signaling and Akt Signaling. TEK encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in TEK are associated with inherited venous malformations of the skin and mucous membranes.
