STAC3 (SH3 And Cysteine Rich Domain 3) is a Protein Coding gene. Diseases associated with STAC3 include Native American Myopathy and Pleomorphic Adenoma Carcinoma. The protein encoded by STAC3 is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in STAC3 are a cause of Native American myopathy.