SKI encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. SKI (SKI Proto-Oncogene) is a Protein Coding gene. Diseases associated with SKI include Shprintzen-Goldberg Syndrome and Goldberg-Shprintzen Megacolon Syndrome. Among its related pathways are SMAD Signaling Network and Development_TGF-beta receptor signaling.
