SGK3 is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. Serum/Glucocorticoid Regulated Kinase Family Member 3 phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
