RAPGEF4 (Rap Guanine Nucleotide Exchange Factor 4) is a Protein Coding gene. Diseases associated with RAPGEF4 include Lesch-Nyhan Syndrome and Acrodysostosis. Among its related pathways are Rap1 signalling and Metabolism. GO annotations related to RAPGEF4 include guanyl-nucleotide exchange factor activity and Ras GTPase binding. An important paralog of RAPGEF4 is RAPGEF3.