ROBO4 (Roundabout Guidance Receptor 4) is a Protein Coding gene. Diseases associated with ROBO4 include Gilles De La Tourette Syndrome. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity. An important paralog of this gene is SDK2. Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).