RNF5 encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. RNF5 (Ring Finger Protein 5) is a Protein Coding gene. Diseases associated with RNF5 include Cystic Fibrosis and Inclusion Body Myositis. Among its related pathways are Protein processing in endoplasmic reticulum and HIV Life Cycle.