PPME1 (Protein Phosphatase Methylesterase 1) is a Protein Coding gene. Diseases associated with PPME1 include Malignant Glioma. PPME1 encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.
