NUAK2 (NUAK Family Kinase 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Glucose / Energy Metabolism. Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate Ser-464 of LATS1.
