NDUFS8 (NADH:Ubiquinone Oxidoreductase Core Subunit S8) is a Protein Coding gene. Diseases associated with NDUFS8 include Leigh Syndrome With Leukodystrophy and Leigh Syndrome. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. NDUFS8 encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria.
