- 中文名称
低密度脂蛋白受体相关蛋白2 多克隆抗体
- 英文名字
- LRP2 Polyclonal Antibody
- 供应商
- 艾美捷
- 产品货号
- ABP59146
- 产品报价
- ￥替代产品
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- The protein encoded by LRP2, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in LRP2 cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
- 应用类型
- IHC-p
- 免疫原
- 合成多肽：来源于人员源 LRP2 蛋白，氨基酸序列为：2890-2970
- 来源宿主
- 兔
- 反应性
- 人、小鼠、大鼠
- 保存建议
- 自发货之日起，-20°C可稳定保存1年。为最大限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。
- 其他
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- 注意
-
该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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