KCNE5 (Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 5) encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of KCNE5 are associated with idiopathic ventricular fibrillation and Brugada syndrome.
