ING1 encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. Inhibitor Of Growth Family Member 1 is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
