The secretory protein encoded by GKN2 (Gastrokine 2) is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. GKN2 may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. GKN2 is a Protein Coding gene. Diseases associated with GKN2 include Gastric Cancer, Somatic and Internuclear Ophthalmoplegia.
