CUL4A (Cullin 4A) is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins. CUL4A is a Protein Coding gene. Diseases associated with CUL4A include Xeroderma Pigmentosum Group E and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and Transcription-Coupled Nucleotide Excision Repair (TC-NER).