NFKBIA（NFKB inhibitor alpha） encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in NFKBIA have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.蛋白别名为：NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3);基因ID为：4792；蛋白质ID:P25963
