TRPV4(transient receptor potential cation channel subfamily V member 4) encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in TRPV4 are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for TRPV4.蛋白别名为:TRPV4 VRL2 VROAC;基因ID为:59341;蛋白质ID:Q9HBA0