The protein encoded by SMARCB1（SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1） is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. SMARCB1 has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for SMARCB1.蛋白别名为：SMARCB1 BAF47 INI1 SNF5L1;基因ID为：6598；蛋白质ID:Q12824
