BRE(brain and reproductive organ-expressed (TNFRSF1A modulator)) encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. BRE is upregulated in several types of cancer. 蛋白别名为:BRE; BRCC45; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein;基因ID为:9577;蛋白质ID:Q9NXR7
应用类型
WB,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:10000. Not yet tested in other applications.
免疫原
合成多肽:the C-terminal region of human BRE. at AA rangle: 300-380