The protein encoded by KLF7 (Kruppel like factor 7)is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of KLF7 is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants.蛋白别名为:KLF7; UKLF; Krueppel-like factor 7; Ubiquitous krueppel-like factor;基因ID为:8609;蛋白质ID:O75840
应用类型
WB,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽:the Internal region of human KLF7. at AA rangle: 150-230