The cytoplasmic peripheral membrane protein encoded by EZR (ezrin)functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for EZR. Alternatively spliced variants have also been described for EZR.蛋白别名为:EZR; VIL2; Ezrin; Cytovillin; Villin-2; p81;基因ID为:7430;蛋白质ID:P15311
应用类型
WB,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽:human Ezrin around the phosphorylation site of T566.