TTK （TTK protein kinase）encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.蛋白别名为：TTK; MPS1; MPS1L1; Dual specificity protein kinase TTK; Phosphotyrosine picked threonine-protein kinase; PYT;基因ID为：7272；蛋白质ID:P33981
应用类型
IHC-p，ELISA补充：最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: IHC-p: 1:100-1:300, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽：human TTK around the phosphorylation site of T676.
