The protein encoded by this intronless gene THBD(thrombomodulin) is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in THBD are a cause of thromboembolic disease, also known as inherited thrombophilia.蛋白别名为:THBD; THRM; Thrombomodulin; TM; Fetomodulin; CD antigen CD141;基因ID为:7056;蛋白质ID:P07204
应用类型
WB,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽:the C-terminal region of human CD141. at AA rangle: 500-580