The protein encoded by STAT4（signal transducer and activator of transcription 4） is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in STAT4 may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.蛋白别名为：STAT4; Signal transducer and activator of transcription 4;基因ID为：6775；蛋白质ID:Q14765
应用类型
WB，IHC-p，ELISA补充：最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300. IP: 2-5 ug/mg lysate. ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽：human Stat4 around the non-phosphorylation site of Y693.
