- 中文名称
Ataxin-1 (phospho Ser776) 多克隆抗体
- 英文名字
- Ataxin-1 (phospho Ser776) Polyclonal Antibody
- 供应商
- 艾美捷
- 产品货号
- ABP56120
- 产品报价
- ￥替代产品
- 产品说明书
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- 购买方式
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- 产品新闻
- 背景资料
- The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for ATXN1（ataxin 1）.蛋白别名为：ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia type 1 protein;基因ID为：6310；蛋白质ID:P54253
- 应用类型
- WB，IHC-p，IF，ELISA补充：最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:10000. Not yet tested in other applications.
- 免疫原
- 合成多肽：human Ataxin-1 around the phosphorylation site of S776.
- 来源宿主
- 兔
- 反应性
- 人，小鼠
- 保存建议
- 厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为最大限度的避免损失，请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中，含50%甘油，0.5%BSA和0.02%NaN3.
- 其他
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- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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