- 中文名称
CD110 多克隆抗体
- 英文名字
- CD110 Polyclonal Antibody
- 供应商
- 艾美捷
- 产品货号
- ABP55267
- 产品报价
- ￥替代产品
- 产品说明书
- 点击查看
- 购买方式
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- 产品新闻
- 背景资料
- In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.蛋白别名为：MPL; TPOR; Thrombopoietin receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD antigen CD110;基因ID为：4352；蛋白质ID:P40238
- 应用类型
- WB，ELISA补充：最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:10000. Not yet tested in other applications.
- 免疫原
- 合成多肽：the Internal region of human CD110.
- 来源宿主
- 兔
- 反应性
- 人
- 保存建议
- 厂家推荐蓝冰运输.在发货后能在-20℃保存1年.为最大限度的避免损失，请在打开管盖之前融化抗体并离心.我们建议使用前分装以避免反复冻融.本产品为液体形式,溶解于PBS缓冲液中，含50%甘油，0.5%BSA和0.02%NaN3.
- 其他
- 艾美捷科技与国内外优秀的生物试剂供应商优保持着密切的合作关系，目前已成为众多国际知名品牌的中国总代理或一级代理，主要包括：AmyJet、AATBioquest、Abbexa、Abnova、Agrisera、Anogen、Atlas Antibodies、Biosensis、Biovision、BioVendor、CaissonLabs、Cell Biolabs、Cytoskeleton、Demeditec、Duchefa、Epigentek、Equitech-Bio、EXBio、Fitzgerald、GeneCopoeia、HycultBiotech、ImmunoReagents、ImmunoStep、Jackson、LifeSensors、LigaTrap、Lumiprobe、Mabtech、Matreya、NorgenBiotek、Origene、ProImmune、ProSpec、ScyTek、SolisBioDyne、SouthernBiotech、StressMarq、SySy、USBiological、TRC等，可以在短时间内为用户提供专业的前沿资讯、完备的产品及物流服务。
- 注意
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该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。
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