Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.蛋白别名为:JDP2; Jun dimerization protein 2;基因ID为:122953;蛋白质ID:Q8WYK2
应用类型
IHC-p,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: IHC-p: 1:100-1:300, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽:human JDP2 around the phosphorylation site of T148.