Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The calpain 9 encoded by CAPN9 is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for CAPN9. 蛋白别名为：CAPN9; NCL4; Calpain-9; Digestive tract-specific calpain; New calpain 4; nCL-4; Protein CG36;基因ID为：10753；蛋白质ID:O14815
应用类型
WB，ELISA补充：最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽：the Internal region of human Calpain 9. at AA rangle: 450-530
