MYO6 encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The unconventional myosin-VI consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. 蛋白别名为：MYO6; KIAA0389; Unconventional myosin-VI; Unconventional myosin-6;基因ID为：4646；蛋白质ID:Q9UM54
应用类型
WB，IHC-p，ELISA补充：最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-300 ELISA: 1:5000. Not yet tested in other applications.
免疫原
合成多肽：the N-terminal region of human Myosin VI. at AA rangle: 40-120
