Musculin encoded by MSC is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. Musculin also forms heterodimers with E2A proteins in vivo. Musculin is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway. 蛋白别名为:MSC; ABF1; BHLHA22; Musculin; Activated B-cell factor 1; ABF-1; Class A basic helix-loop-helix protein 22; bHLHa22;基因ID为:9242;蛋白质ID:O60682
应用类型
WB,IHC-p,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:10000. Not yet tested in other applications.
免疫原
合成多肽:the C-terminal region of human Musculin. at AA rangle: 100-180