MLKL belongs to the protein kinase superfamily. Mixed lineage kinase domain-like protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. Mixed lineage kinase domain-like protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. 蛋白别名为：MLKL; Mixed lineage kinase domain-like protein;基因ID为：197259；蛋白质ID:Q8NB16
应用类型
WB，ELISA补充：最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽：the N-terminal region of human MLKL. at AA rangle: 40-120
