DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development.MBD3 belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). Methyl-CpG-binding domain protein 3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.蛋白别名为：MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3;基因ID为：53615；蛋白质ID:O95983
应用类型
WB，ELISA补充：最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:10000. Not yet tested in other applications.
免疫原
合成多肽：the C-terminal region of human MBD3. at AA rangle: 190-270
