DES encodes a muscle-specific class III intermediate filament. Homopolymers of desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in DES are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.蛋白别名为:DES; Desmin;基因ID为:1674;蛋白质ID:P17661
应用类型
WB,IHC-p,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:20000. Not yet tested in other applications.
免疫原
合成多肽:human Desmin around the non-phosphorylation site of S60.