CHAT encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. CHAT product(choline O-acetyltransferase)is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in CHAT have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in CHAT are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for CHAT, and some of these variants have been shown to encode more than one isoform.蛋白别名为:CHAT; Choline O-acetyltransferase; CHOACTase; ChAT; Choline acetylase;基因ID为:1103;蛋白质ID:P28329
应用类型
WB,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, ELISA: 1:10000. Not yet tested in other applications.