Protein kinase D2 encoded by PRKD2 belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. Protein kinase D2 can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.蛋白别名为:PRKD2; PKD2; HSPC187; Serine/threonine-protein kinase D2; nPKC-D2;基因ID为:25865;蛋白质ID:Q9BZL6
应用类型
WB,IHC-p,ELISA补充:最优的抗体稀释比例需要基于客户实验进行优化.建议的起始稀释比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:40000. Not yet tested in other applications.
免疫原
合成多肽:human PKD2 around the phosphorylation site of S876.