Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer，together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells，leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3')，an immune-specific regulatory element，followed by cooperative binding of BATF and IRF4 and activation of genes.
应用类型
Western Blot: 1:1000-1:2000, IHC: 1:200-1:800
免疫原
A peptide corresponding to the C-terminus of human MUM1/IRF4.
