Stathmin (STMN1)，a member of the stathmin family，is also known as Leukemia-associated phosphoprotein p18，Oncoprotein 18 (Op18)，Phosphoprotein p19 (pp19)，Protein Pr22 and pp17，which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric ,B-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex，tubulin becomes non-polymerizable. Without tubulin polymerization，there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.
应用类型
Western Blot: 1:2000-1:5000, IHC: 1:500-1:1000
免疫原
A peptide corresponding to C-terminus of human Stathmin
