COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drμgs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throμghout the body，whereas PGs formed by COX-2 primarily mediate pain，fever，and inflammation. COX-1 is constitutively expressed，with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans，COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity. It has been suggested COX-3 as the key to unlocking the mystery of the mechanism of action of acetaminophen.
应用类型
IHC: 1:500-1:1000, Western Blot: 1:1000-1:20000
免疫原
A peptide corresponding to the C-terminus of human COX-2.
