MART-1 (also known as Melan-A) is a melanocyte differentiation antigen or marker recognized by autologous cytotoxic T lymphocytes. It is a membrane protein with one transmembrane peptide. Melan-A is expressed by a large proportion of melanoma tumors，both melanotic and amelanotic and by melanoma cell lines. It is present in melanocytes of normal skin and retina，nevi and in more than 85% of melanomas. Melan-A/MART-1 is not expressed by non-melanoma malignancies. It is recognized by autologous cytotoxic T lymphocytes. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. Six other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1，Tyrosinase，gp100，gp75，BAGE-1，and GAGE-1.
应用类型
Western Blot: 1:500-1:1000, IHC: 1:500-1:1000
免疫原
A peptide corresponding to the N-terminus of human MART1 (Melanoma antigen recognized by T-cells-1).
