May regulate the expression of IL-2，IL-6，and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.IκBNS，the nuclear IκB-like protein encoded by Nfkbid，is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.IκBNS has been identified as a member of the IκB family of NF-κB inhibitors，which undergoes induction upon TCR signaling. IκBNS mediates both positive and negative gene regulation，depending on individual cell type and/or cytokine.
应用类型
Immunohistochemistry (IHC), Western Blotting, ELISA
