This gene encodes a member of the acyl-CoA thioesterase protein family，and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. Acyl-CoA thioesterases，such as ACOT2，are a group of enzymes that hydrolyze Coenzyme A (CoA) esters，such as acyl-CoAs，bile CoAs，and CoA esters of prostaglandins，to the corresponding free acid and CoA. ACOT2 shows high acyl-CoA thioesterase activity on medium- and long-chain acyl-CoAs，with an optimal pH of 8.5. It is most active on myristoyl-CoA but also shows high activity on palmitoyl-CoA，stearoyl-CoA，and arachidoyl-CoA.
应用类型
Immunohistochemistry (IHC), Western Blotting, ELISA
