Pyk2 a nonreceptor tyrosine kinase of the Fak family. Predominantly expressed in the cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for G-protein-coupled receptors. Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. Interacts with the SH2 domain of Grb2.
应用类型
Immunohistochemistry (IHC), Western Blotting, ELISA
免疫原
A synthesized peptide derived from human PYK2 around the phosphorylation site of Tyrosine 580.
