Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.
应用类型
Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA
免疫原
A synthesized peptide derived from human HBP1 around the phosphorylation site of Sersine 402.
