The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling，through phosphorylations and protein-protein interactions. Modulates signaling in ERK，SRC and NF-kappa-B pathways. In activated T-cells，influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds，together with KLF4，the PE21 promoter element of TP53 and represses TP53 activity.
应用类型
Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA
免疫原
A synthesized peptide derived from human CD227/MUC1 around the phosphorylation site of Tyrosine 1229
