Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE)，both for nuclear and mitochondrial DNA，and as a modulator of other transcription factors. Affects inflammatory responses，cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A，leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.
应用类型
Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA
免疫原
A synthesized peptide derived from human GR around the phosphorylation site of Sersine 203.
