Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation，cell migration，or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.
应用类型
Immunohistochemistry (IHC), Western Blotting, ELISA
免疫原
A synthesized peptide derived from human PAK3 around the phosphorylation site of Sersine 154
