Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands，all-trans or 9-cis retinoic acid，and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand，the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation，chromatin condensation and transcriptional suppression. On ligand binding，the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation
应用类型
Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting
免疫原
A synthesized peptide derived from human Retinoic Acid Receptor alpha around the phosphorylation site of Sersine 77
