The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines，this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK，MAPK14/p38-alpha，and MAPK11/p38-beta. In vitro，this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
应用类型
Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting, ELISA
免疫原
A synthesized peptide derived from human MAPKAPK5 around the phosphorylation site of Threonine 182
