Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). With KLF2，acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney . Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells，which regulate acid-base and salt-water homeostasis，respectively.
