Functions as a receptor for membrane-bound ligands Jagged1，Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation，proliferation and apoptotic programs.
应用类型
WB
免疫原
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NOTCH3
